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Outcome

OA PUBLICATIONS

  1. 1H, 13C and 15N chemical shift assignments of Rubella virus macro domain in the free and in the ADPr bound state. Moschidi D, Fourkiotis NK, Sideras-Bisdekis C, Tsika AC, Spyroulias GA. Biomol NMR Assign. 2025 Jun;19(1):117-125. doi: 10.1007/s12104-025-10227-4. Epub 2025 Apr 5. PMID: 40186845
  2. Structure-based rational design of a selective hydrolase inhibitor of the SARS-CoV-2 Nsp3 macrodomain. Krishnathas, K. Mineev, N.K. Fourkiotis, F. Touret, Ch. Sideras-Bisdekis, A.C. Tsika, S. Lakshmi Gande, V. Linhard, S. Sreeramulu, F. Lennartz, M.S. Weiss, B. Coutard, G.A. Spyroulias, H. Schwalbe. Chembiochem. 2025 Nov 27;26(23):e202500593,https://doi.org/10.1002/cbic.202500593.Epub 2025 Nov 2. PMID: 41176653.

And the following data has been deposited in Open Access repositories:

BMRB (Biological Magnetic Resonance Bank)

52869     1H, 13C and 15N chemical shift assignments of Rubella virus macro domain in the free state (2025)

52870     1H, 13C and 15N chemical shift assignments of Rubella virus macro domain in the ADPr bound state (2025)

PRESENTATIONS

Presentation in Conferences & Scientific Events and Invited Seminars; (O): Oral, (P): poster presentation

  1. 26/09/2024 –29th Panhellenic Chemistry Conference, September 25-28, 2024, National Kapodistrian University of Athens, GREECE. (O)
  2. 16-18/10/2024 – “Adapting to change – Emerging Infectious Diseases in a Shifting Climate”, Institute Pasteur, Paris, FR. (P)
  3. 13/11/2024 –Autonomous University of Barcelona, Barcelona. ES. (O)
  4. 08/12/2024 –GPSF Career Month, December 08, 2024, U of Patras, GR. (O)
  5. 12-15/12/2024 – Young Investigators Meeting & 74o HSBMB, Thessaloniki, GR. (P)
  6. 03-05/04/2025 – 20th Hellenic Symposium on Medicinal Chemistry. (P)
  7. 08/04/2025 –Medical School, U of Patras, GR. (O)
  8. 10/04/2025 European Conference on Allostery in Drug Discovery, BRFAA, Athens, GR. (O)
  9. 11/05/2025 – “FEBS Advanced Course: PARP2025: from molecular aspects to clinical applications”, Illkirch, Strasbourg, FR. (O)
  10. 03/07/2025 – 1st International Meeting on RNA & RNases, Barcelona, ES. (O)
  11. 07-23.07 2025 – MILESTONE International Conference, Brno, Czech Republic (O)
  12. 07-09.07 2025 – FEBS 2025 Congress, Istanbul, Turkey (P)
  13. 06-03.07 2025 – Helicases and Nucleic Acid-Based Machines, Lisbon Portugal (O)
  14. 10-26.10 2024 – Advances in Noncanonical Nucleic Acids, Portorož, Slovenia (O)
  15. 09-27.09 2024 – Wnt Meeting 2024, Heidelberg, Germany (P)
  16. 4/10/2024 – Advances in Noncanonical Nucleic Acids (ANNA) 2024, October 24-26, 2024; Maja Marušič (NIC) (O)
  17. 25/10/2024 – Advances in Noncanonical Nucleic Acids (ANNA) 2024, October 24-26, 2024; Kostantinos Tripsianes (CEITEC) (O)
  18. 06/11/2024 – workshop Basics of Methodological Approaches in Structural Biology, Instuct SI, Ljubljana, Slovenia, November 11, 2024; Maja Marušič (NIC) (O)
  19. 20/02/2025 – webinar-series 2025 – XIV, Nucleic Acid Secondary Structures: G4s and Beyond, February 20, 2025; Janez Plavec (NIC) (O)
  20. 24/02/2025 – INTERACTION WINS 2025, University of Pavia, Italy, February 24-28, 2025; Janez Plavec (NIC) (O)
  21. 07/03/2025 – “To B or Not to B” Workshop 2025 at FIBER, Konan University, Kobe, Japan, March 7-8, 2025; Janez Plavec (NIC) (O)
  22. 10/04/2025 – Trends in Nucleic Acid (TINA) 2025, Nankai University, Tianjin, China, April 10-12, 2025; Janez Plavec (NIC) (O)
  23. 05/06/2025 – G4thering nucleic acid conference, Minneapolis, Minnesota, USA, June 2-6, 2025; Janez Plavec (NIC) (O)

NEW NATIONAL & EU PROJECTS

UPAT:

National Grants:

1) HFRI (Hellenic Foundation for Research & Innovation, Greece), 3rd Call for H.F.R.I.’s Research Projects to Support Faculty Members & Researche: “TALENT: Novel Soluble GuanylaTe Cyclase StimulAtors: RationaL Design-Driven Optimization and CharactErization of their Unique MechaNism of AcTion”. Proposal ID 26699, 2025-2028. PI: G.A.Spyroulias

2) HFRI (Hellenic Foundation for Research & Innovation, Greece), 2nd H.F.R.I. Call for the Procurement of High-value Research Equipment – “iMELODY – iMplementation of nEw tooLs to bOost the Drug discoverY pipeline at the Department of Pharmacy/UPAT”, Proposal ID 18879. Purchase and sinstallation of a Biolayer Interferometry and a Microscale Thermophoresis “Monolith X” equipment (PI a faculty member of Dept of Pharmacy, UPAY, Prof. E. Papadimitriou)

EU Grants:

1) HORIZON-MSCA-2024-SE-01 (MSCA STAFF EXCHANGE, European Union) – “GuardAgents: Study of Novel Generation nanobodies for agri-food applications”,  GA 101236168, 2025-2029. UPAT’s PI: G.A.Spyroulias

 

MU/CEITEC:

National Grants:

1) Touching the untouchable; biochemistry of full-length Vangl2 protein (8J25FR012), 01/2025-12/2026, Ministry of Education, Youth and Sports of the CR / Mobility Activity;

2) Structural insights into the function of the key planar cell polarity regulator Vangl2 (GA25-17258S), 01/2025-12/2027, Czech Science Foundation / Standard Projects;

3) Structural biology of the Wnt/PCP signaling pathway (LUAUS25170), 03/2025-12/2028, Ministry of Education, Youth and Sports of the CR / INTER-EXCELLENCE II.

EU Grants:

1) HORIZON-MSCA-2024-SE-01 (MSCA STAFF EXCHANGE, European Union) – “GuardAgents: Study of Novel Generation nanobodies for agri-food applications”,  GA 101236168, 2025-2029. CEITEC’s PI: K. Tripsianes

MILESTONE objectives define the pathway to synergies among partners for future sustainability.