CK1 protein kinase family: From cell signaling to therapeutic targets in human disease
July 21–23, 2025
CEITEC MU, Brno, Czech Republic
CK1 (formerly named casein kinase 1) is a family of serine/threonine protein kinases crucial for regulating multiple cellular processes. Defects in CK1 regulation, localization, or mutations within the CK1 coding sequence are associated with important human diseases such as cancer, neurodegenerative diseases, and sleeping disorders. Consequently, members of the CK1 protein kinase family have emerged as promising targets for novel drug development, each paralog exhibiting distinct therapeutic effects. Furthermore, there is growing evidence linking CK1 to infectious diseases through the manipulation of its signaling pathways by pathogens.
The primary objective of the inaugural conference was to share the latest research findings on CK1. Beyond that, the conference aimed to foster collaboration among diverse scientific communities engaged in CK1 research, thereby encouraging the exploration of new avenues in CK1-related studies.
The conference sessions encompassed the following areas:
CK1 in development and regeneration
Exploring CK1 function in model organisms
CK1 structure and mechanisms of regulation
CK1 and circadian clocks
CK1 in human diseases: cancer
CK1 in human diseases: neurodegenerative diseases
CK1 in human diseases: infectious diseases
Spatial and temporal aspects of signaling
Targeting CK1 for therapy
You can download the flyer here.